Cov teebmeem ntawm probiotic rau cov tsos mob ntawm tus kab mob Parkinson

Dr. Valentina Leta yog ib tug kws kho mob hlwb thiab kws tshawb fawb txog kev txav mus los uas muaj kev txaus siab tshwj xeeb hauv kev ua haujlwm tsis zoo ntawm lub plab thiab txoj hnyuv hauv cov neeg mob Parkinson, thiab tam sim no nws ua haujlwm ntawm Instituto Neurologica Carlo Besta hauv Milan, Ltalis. Thiab Dr. Ray Chaudhuri yog tus Thawj Coj ntawm Kev Tshawb Fawb thiab Kev Sim Tshuaj ntawm King's College Hospital, London hauv Dubai United Arab Emirates, thiab yog xibfwb ntawm King's Parkinson's Center of Excellence hauv Dubai, thiab xibfwb ntawm Dement Tech Neuroscience Clinical Academic Center hauv London.

Peb yuav tham txog [00:01:00] lawv tsab xov xwm tsis ntev los no hauv Phau Ntawv Xov Xwm Txog Kev Txav Mus Los, Cov Nyhuv ntawm Plaub Hom probiotic rau Gut Microbiota, Kev Mob thiab Cov tsos mob hauv Parkinson's Disease. Thiab qhov no yog kev sim tshuaj randomized.

Yog tias peb cov neeg mloog tseem tsis tau ua li ntawd, kuv xav kom koj rov qab mus rau ntu 111 ntawm MDS Podcast, uas yog ntu Hot Topic txog cov kab mob hauv plab hauv tus kab mob Parkinson.

Thiab qhov no muaj feem cuam tshuam nrog kev sib tham uas peb yuav muaj hnub no. Peb yuav pib nrog koj Ray. Kuv tsuas xav kom koj qhia rau peb paub tias txoj kev tshawb fawb no los qhov twg los. Nws tau tsim li cas?

Dr. Kallol Ray Chaudhuri: Ua tsaug, Sara, rau qhov caw peb tuaj koom podcast no. Zoo siab uas tau nyob ntawm no nrog Valentina. Yog lawm. Txoj haujlwm tau pib los ntawm kev pom thiab kev paub dhau los ntawm kuv tus neeg mob uas tu siab tau tas sim neej tsis ntev los no, tab sis muaj Parkinson's thiab muaj Parkinson's tau ntau xyoo.

Thiab nws tau nyeem txog lub plab thiab [00:02:00] teeb meem microbiota ntau xyoo dhau los thiab tau nug kuv, seb nws puas yuav tsum sim siv qee cov probiotics ua haujlwm rau microbiota, thiab nws tau pom cov probiotic tshwj xeeb no thiab tau siv nws thiab tuaj rau kuv hais tias txij li thaum nws tau noj cov probiotic tshwj xeeb no, nws tau xav tias zoo dua hauv nws tus kheej.

Nws tau hnov ​​​​​​lub zog ntau thiab tshwj xeeb nws hais tias nws tau taug kev mus rau kuv lub tsev kho mob thawj zaug uas nws tsis tau ua ua ntej. Nws tuaj yeem raug suav hais tias yog ntau yam, tab sis nws ncaj qha rau qhov no, rau lub zog thiab lub zog uas nws muaj txij li thaum nws tau siv symprove. Thiab qhov no tau pom zoo los ntawm nws tus txiv, uas tom qab ntawd, rov hais dua kom kuv pom, vim li cas koj tsis ua qhov kev sim? Vim li cas koj tsis ua qhov kev sim? Yog li ntawd coj kuv mus tham txog qhov project no nrog cov neeg ua symprove, uas kuv tau mus cuag thiab xav muab nws los ntawm kev sim tshuaj [00:03:00]. Uas yog li cas peb tuaj txog ntawm qhov kev sim.

Thiab tau kawg, Valentina tom qab ntawd tau ua tus thawj coj ntawm kev sim tshuaj, uas tom qab ntawd peb tau txais nyiaj los ntawm peb tus kheej los khiav qhov kev sim tshuaj. Yog li kuv xav tias qhov no yog ib qho piv txwv tiag tiag thaum kev paub dhau los ntawm tus neeg mob tau ua rau muaj kev tsim cov kev sim tshuaj thoob ntiaj teb uas tswj hwm los ntawm ob tog uas tsis pom kev. Thiab tom qab ntawd cov ntaub ntawv tom qab ntawd uas peb yuav tham txog.

Yog li keeb kwm yog qhov nthuav heev uas qhov kev paub ntawm tus neeg mob yuav tseem ceeb heev rau peb los tsim lossis xav txog kev sim tshuaj ntawm cov tshuaj molecule lossis cov khoom uas lawv yuav pom tias muaj txiaj ntsig.

Dr. Sara Schaefer: Qhov ntawd yog lub hom phiaj kawg, xaus rau tus neeg mob thiab kuv nyiam tias koj tab tom pib nrog tus neeg mob thiab. Valentina, koj puas tuaj yeem coj peb mus rau qhov paub txog hom kab mob Parkinson thawj zaug, thiab qhov laj thawj rau kev siv probiotics hauv cov pej xeem no.

Ua ntej koj txoj kev tshawb fawb [00:04:00], kev tshawb fawb txog tsiaj txhu thiab tib neeg tau ua pov thawj dab tsi?

Dr. Valentina Leta: Ua tsaug rau koj Sara, dua rau qhov muaj peb nyob ntawm no. Thiab yog koj tej zaum paub tias tsis ntev los no cov xov xwm ntawm kev faib tawm ntaus ntawv tau raug thov rau tus kab mob Parkinson. Lub cev ua ntej piv rau lub hlwb ua ntej tus kab mob Parkinson. Yog li hauv lub hlwb ua ntej peb xav tias qhov kab mob yuav pib theem ntawm lub paj hlwb hauv nruab nrab, qhov substantia nigra nrog kev txhim kho ntawm Parkinsonism, thiab tom qab ntawd qhov kab mob yuav kis mus rau lub hlwb nrog kev txhim kho ntawm RBD thiab tom qab ntawd mus rau lub paj hlwb peripheral nrog lwm cov tsos mob tsis yog lub cev xws li orthostatic hypotension thiab cem quav. Thaum lub cev ua ntej tus kab mob Parkinson, qhov kab mob yuav pib tiag tiag ntawm theem ntawm lub paj hlwb peripheral thaum ntxov nrog cem quav thiab orthostatic hypotension ua ib qho prodromal feature thiab tom qab ntawd kis mus rau lub hlwb nrog locus [00:05:00] thiab muaj prodromal RBD thiab tom qab ntawd cuam tshuam rau qhov substantia nigra nrog kev txhim kho ntawm Parkinsonism. Tam sim no muaj ntau qhov kev txwv rau tus qauv no feem ntau los ntawm kev tshawb fawb postmortem. Peb tuaj yeem pom cov phenotypes hauv peb txoj kev kho mob.

Muaj ib txhia neeg mob uas muaj ntau yam tsos mob tsis yog lub cev thaum pib mob thiab ib txhia neeg mob uas lawv tsis muaj tsos mob tsis yog lub cev ua ntej muaj tus kab mob Parkinson. Yog tias peb tsom mus rau lub cev ua ntej, ces yuav muaj tus kab mob Parkinson. Qhov tseeb, hom kab mob no yuav muaj feem cuam tshuam rau txoj hnyuv plab thiab txoj hnyuv thaum ntxov.

Thiab peb paub tias kev ua haujlwm tsis zoo ntawm lub plab zom mov yog qhov tshwm sim ntau heev rau cov neeg mob uas muaj tus kab mob Parkinson. Piv txwv li, cem quav yog ib qho ntawm cov yam ntxwv prodromal thiab yog qhov ua rau muaj kev pheej hmoo rau kev loj hlob ntawm tus kab mob Parkinson. [00:06:00] Thiab qhov no tau teeb tsa hauv av rau kev tshawb nrhiav ntawm cov kab mob hauv plab hauv cov neeg uas muaj Parkinson. Cov kab mob hauv plab yog cov pas dej ntawm cov kab mob, cov kab mob fungi, cov kab mob, cov protozoa, uas nyob hauv peb txoj hnyuv, thiab lawv yeej tseem ceeb heev rau tib neeg kev noj qab haus huv. Lawv tuaj yeem hloov pauv cov metabolism, lawv tuaj yeem hloov pauv cov haujlwm thaiv ntawm txoj hnyuv. Lawv tuaj yeem hloov pauv kev o, kev sib kis ntawm cov hlab ntsha, thiab qhov tseeb cov yam ntxwv no kuj hloov pauv hauv tus kab mob Parkinson.

Qhov twg peb muaj qhov xwm txheej pro-inflammatory, peb paub tias qhov ntawd yog ntau yam neurotransmitter teeb meem cuam tshuam tsis yog tsuas yog dopamine, tab sis kuj serotonin, acetylcholine, thiab lwm yam. Thiab peb kuj muaj qhov mob plab hnyuv. Yog li qhov xwm txheej uas peb muaj kev nce ntxiv ntawm cov hnyuv mucosa. Tam sim no ntau yam kev tshawb fawb tau saib [00:07:00] ntawm cov kab mob plab hauv cov neeg mob uas muaj tus kab mob Parkinson.

Thiab qhov tseem ceeb tshaj plaws qhov kev tshawb pom yog qhov xwm txheej pro-inflammatory uas qhov kev o tuaj yeem ua rau muaj alpha synuclein pathology. Thiab ntawm ntau yam kev hloov pauv uas tau rov ua dua, muaj qhov txo qis ntawm cov kab mob luv luv uas tsim cov roj fatty acid. Cov roj fatty acid luv luv yog cov metabolites, uas muaj txiaj ntsig vim tias lawv txo qhov o, thiab cov no tau teeb tsa hauv av rau kev siv cov kab mob hauv plab modulating hauv Parkinson tus kab mob, suav nrog probiotics. Uas tau txhais los ntawm WHOS cov kab mob nyob, uas tuaj yeem muab cov txiaj ntsig zoo rau tus tswv tsev.

Dr. Kallol Ray Chaudhuri: Yog tias kuv tsuas yog ntxiv ib kab lus rau Valentina cov ntsiab lus tseem ceeb uas lub cev ua ntej, lub hlwb ua ntej yog [00:08:00] qhov tseeb tau los ntawm cov lus piav qhia los ntawm sour Beer etal hauv xyoo 2015. Qhov twg peb tau koom nrog hauv qhov ntawd piav qhia peb lub hauv paus ib qho yog brainstem, ib qho yog limbic, lwm qhov yog cognitive lossis neocortical.

Thiab qhov tseeb, lub cev ua ntej qhia txog txoj kev limbic thiab brainstem. Thiab qhov tseeb, nws kuj tau piav qhia los ntawm cov neurotransmitters, thiab Valentina thiab kuv, peb ob leeg tau piav qhia txog hom noradrenergic subtype, uas sib tshooj nrog lub cev thawj cov kev xav, tab sis qhov tseem ceeb yog tias lub plab tsis ua haujlwm, raws li Valentina tau hais. Qhov project tshwj xeeb no tau tsom mus saib seb qhov ntawd puas tuaj yeem daws tau los ntawm kev siv cov tshuaj probiotic uas tsis yog tshuaj, uas nkag mus rau hauv plab loj.

Dr. Sara Schaefer: Thiab Ray, kuv xav tsis thoob tias koj puas tuaj yeem piav qhia me ntsis txog yam uas tau pom hauv cov tsiaj thiab tib neeg txog [00:09:00] kev siv probiotic rau Parkinson's lossis Parkinson's qauv.

Dr. Kallol Ray Chaudhuri: Yog lawm, yog li muaj ntau yam kev ua haujlwm ua ntej qhia tau tias, tshwj xeeb tshaj yog hauv symprove, thiab Valentina tuaj yeem ntxiv rau qhov ntawd thiab, hauv cov qauv nas uas qhia tias, microbiota tuaj yeem nplua nuj nrog qee cov kab mob tiv thaiv kab mob los ntawm kev siv symprove. Qhov no tau pom hauv cov qauv rau cov kab mob plab hnyuv thiab piv txwv li hauv pawg mob plab hnyuv thiab tej zaum hauv cov kab mob plab hnyuv. Thiab peb kuj tau tshaj tawm ua ke nrog pawg preclinical ntawm University College of London.

Peb kuj tau tshaj tawm cov ntaub ntawv uas ua rau nws tus kheej zoo dua hauv cov qauv nas no muaj txiaj ntsig rau kev nplua nuj ntawm cov kab mob plab thiab tej zaum Valentina, koj puas xav hais ntxiv me ntsis txog qhov ntawd?

Dr. Valentina Leta: Yog, ua tsaug Ray. Yog tshwj xeeb [00:10:00] hais txog tus kab mob Parkinson, peb tau tshuaj xyuas cov ncauj lus ua ntej teeb tsa kev tshawb fawb, thiab peb paub tias los ntawm kev tshawb fawb ua ntej, kev siv probiotics yuav muaj qee yam khoom tiv thaiv neuroprotective tshwj xeeb nws tau pom tias probiotics tuaj yeem ua rau cov yam ntxwv neurotrophic nce ntxiv, qib ntawm qib ntawm lub paj hlwb hauv nruab nrab, tab sis kuj tseem muaj dopaminergic neurons hauv substantia nigra ntawm cov qauv tsiaj ntawm tus kab mob Parkinson.

Lawv tej zaum yuav muaj cov tshuaj tiv thaiv kev o thiab cov tshuaj antioxidant ntawm theem ntawm lub paj hlwb hauv nruab nrab thiab kuj ntawm theem systemic. Thiab thaum kawg, yog tias peb saib cov cim qhia txog kev txav mus los thiab cov cim tsis yog kev txav mus los, kev siv probiotic tau cuam tshuam nrog kev txhim kho ntawm kev txav mus los thiab kev nco tsis zoo ntawm lwm yam ntxwv tsis yog kev txav mus los hauv tsiaj txhu ntawm Parkinson's.

Txawm li cas los xij, [00:11:00] thaum nws los txog rau kev tshawb fawb hauv tsev kho mob cov kev tshawb pom no tsuas yog txhais ib feem xwb thiab qhov tseeb, lub sijhawm no, peb tsuas muaj pov thawj theem ib rau kev siv probiotics los tswj kev cem quav rau cov neeg uas muaj tus kab mob Parkinson.

Dr. Sara Schaefer: Yog li ntawd, yog tias peb xav txog txhua yam uas peb paub txog tam sim no, koj tau tsim koj txoj kev tshawb fawb li cas thiab koj tau saib cov txiaj ntsig zoo li cas? Valentina.

Dr. Valentina Leta: Peb tau txiav txim siab ua qhov kev sim tshuaj placebo ob chav dig muag uas tshawb nrhiav cov teebmeem ntawm plaub hom probiotic tshwj xeeb no rau cov kab mob hauv plab hnyuv ntawm cov cim qhia txog kev mob plab hnyuv thiab lub cev thiab cov yam ntxwv ntawm lub cev thiab cov yam ntxwv tsis yog lub cev ntawm tus kab mob Parkinson. Peb tau nrhiav tus neeg mob 74 uas muaj tus kab mob Parkinson thiab cem quav vim peb xav tsom peb txoj kev tshawb fawb rau cov neeg mob [00:12:00] nrog cov pov thawj meej ntawm kev koom tes hauv plab hnyuv.

Thiab cov neeg koom nrog tau muab faib rau ob pawg, pawg nquag thiab pawg placebo, thiab lawv tau raug saib xyuas rau 12 lub hlis. Yog li peb muaj qhov pib thiab 12 lub lis piam kev ntsuam xyuas, uas yog raws li roj teeb ntawm cov nplai raug lees paub thiab cov lus nug rau cov tsos mob ntawm lub cev thiab tsis yog lub cev. Peb kuj tau sau cov qauv quav thiab ntshav los ua, kev tshuaj xyuas cov qauv tshuaj lom neeg no. Thiab qhov tseem ceeb peb tau txiav txim siab los tsom mus rau qhov kev hloov pauv ntawm cov kab mob hauv plab, uas yog peb qhov tshwm sim tseem ceeb. Tom qab ntawd cov txiaj ntsig thib ob. Peb tau saib cov kev hloov pauv hauv cov cim qhia kev mob thiab sab nraud, thiab thaum kawg peb xav tshawb nrhiav cov txiaj ntsig zoo ntawm cov probiotic no rau cov tsos mob ntawm lub cev thiab tsis yog lub cev, uas sawv cev rau peb cov txiaj ntsig tshawb nrhiav [00:13:00].

Dr. Sara Schaefer: Koj nrhiav tau dab tsi?

Dr. Valentina Leta: Yog li ua ntej tshaj plaws, peb pom tias ob pawg neeg tau sib npaug zoo heev hauv kev sib raug zoo hauv zej zog, cov yam ntxwv kho mob, thiab cov ntsuas kev sib txawv ntawm cov kab mob hauv plab. Qhov ntawd zoo heev vim nws txhais tau tias qhov kev xaiv tsa tau ua tiav thiab ob pawg neeg sib piv. Thiab tsom mus rau qhov ntsuas qhov tshwm sim tseem ceeb.

Peb tsis tau pom muaj kev hloov pauv tseem ceeb ntawm cov pab pawg hauv cov ntsiab lus ntawm alpha thiab beta ntau yam kev ntsuas, uas txhais tau tias qhov kev cuam tshuam tsis tau hloov pauv dav dav ntawm cov kab mob hauv plab ntawm cov tib neeg no. Qhov no tseem ceeb heev vim peb tsis xav hloov pauv dav dav ntawm cov kab mob hauv plab, tab sis kev cuam tshuam tsom mus rau yuav tsum hloov qee yam taxa lossis kev ua haujlwm. Yog li nrog qhov sib txawv [00:14:00] kev tshuaj xyuas ntau, peb tau txheeb xyuas tias qhov kev cuam tshuam nquag, probiotic, tau cuam tshuam nrog kev muaj ntau ntxiv ntawm qee cov kab mob, uas paub zoo tias muaj cov khoom zoo rau kev noj qab haus huv xws li cov kab mob, Odoribacteraceae tsev neeg, uas paub tias cuam tshuam nrog kev laus noj qab haus huv.

Los yog piv txwv li, Blautia faecicola, uas yog cov kab mob uas tsim cov roj fatty acid luv luv, uas paub tias raug txo qis hauv cov neeg mob uas muaj Parkinson's. Yog li cov no yog cov txiaj ntsig zoo heev. Thiab tom qab ntawd saib cov txiaj ntsig thib ob. Peb pom muaj kev txo qis ntawm cov cytokine pro-inflammatory TNF-α thiab saib cov txiaj ntsig tshawb nrhiav, muaj qee cov cim zoo rau kev txo qis ntawm cov tsos mob tsis yog lub cev, uas peb paub tias nws muaj feem cuam tshuam nrog lub neej zoo.

Thiab qhov no yog [00:15:00] tsav los ntawm kev txhim kho hauv kev cem quav thiab qaug zog, uas yog qhov nthuav heev rau kev saib xyuas.

Dr. Sara Schaefer: Yog li ntawd, thaum koj muab tag nrho cov ntaub ntawv no ua ke, koj tau muab rau kuv ib daim ntawv teev npe loj heev ntawm cov khoom uas cov probiotics tab tom hloov pauv hauv cov pej xeem no. Koj xav li cas tiag tiag tshwm sim pathophysiologically? Cov probiotics ua dab tsi tiag tiag los pab cov neeg mob?

Dr. Valentina Leta: Yog li kuv ntseeg tias qhov kev piav qhia zoo tshaj plaws yuav yog tias los ntawm kev siv probiotics peb tuaj yeem txhim kho kev cem quav. Yog li peb tuaj yeem txo qhov kev cuam tshuam no rau kev thauj mus los thiab kev nqus ntawm tus qauv kub rau tus kab mob Parkinson, uas yog qhov ncauj levodopa. Thiab yog li los ntawm kev nqus tau zoo dua levodopa, peb tuaj yeem muaj kev txo qis ntawm lub sijhawm mus rau ON, uas kuj yog lwm qhov kev tshawb pom uas peb tau pom. Yog li lub sijhawm rau cov tshuaj kom pib, kom pib thiab kuj ntawm qee yam tsis yog lub cev uas yuav yog dopaminergic [00:16:00] teb. Lwm qhov kev piav qhia tau, uas yog me ntsis ntxiv kev kwv yees, yog tias cov probiotics tuaj yeem txo qhov mob plab hnyuv los ntawm kev hloov pauv cov kab mob plab hnyuv, thiab qhov no tuaj yeem ua rau txo qis ntawm qhov xwm txheej mob systemic, thiab cov no thaum kawg tuaj yeem ua rau kev txhim kho qee cov tsos mob tsis yog lub cev xws li qaug zog, uas paub tias muaj feem cuam tshuam nrog kev mob, ib feem tsawg kawg. Tab sis qhov no tseem yog me ntsis ntxiv kev kwv yees raws li kev xav.

Dr. Sara Schaefer: Qhov no zoo li muaj kev cia siab tias yuav muaj kev txhim kho zoo, tsis yog tsuas yog cov tsos mob uas tsis yog los ntawm lub cev xwb, tab sis kuj muaj peev xwm ua rau qee cov tsos mob ntawm lub cev ntawm cov neeg mob no. Yog li koj puas khiav mus rau koj lub tsev kho mob thiab qhia rau txhua tus neeg mob kom pib noj probiotics lossis koj xav li cas tias qhov no txhais tau li cas rau hauv qhov chaw kho mob tam sim no?

Dr. Kallol Ray Chaudhuri: Kuv xav tias qhov no tam sim no yog tus kheej heev [00:17:00] tus kheej, kev sau tshuaj rau tus kheej hauv cov kws kho mob sib txawv thiab cov kws tshaj lij kev kho mob. Hauv kuv tus kheej kev kho mob, peb tau piav qhia thiab tshaj tawm rau ntawm lub dashboard rau Parkinson, uas yog qee cov qauv yooj yim uas yuav tsum tau ua tiav thiab kev txhim kho kev noj qab haus huv ntawm txoj hnyuv yog ib qho ntawm lawv.

Kev daws teeb meem cem quav, daws teeb meem kev nqus levodopa los ntawm kev txo cov khoom noj mis nyuj nrog levodopa, thiab lwm yam. Thiab kuv xav tias cov lus coj mus tsev los ntawm qhov kev sim no thiab nws tau ua tiav, ob chav dig muag placebo tswj kev sim, yog tias nws zoo li plaub hom probiotic ntawm no zoo li yuav txhim kho koj lub sijhawm kom ON.

Yog li ntawd, yog tias qhov ntawd yog qhov tseeb, kuv feem ntau siv dopa noj cov neeg mob uas hnav OFF. Kuv twb thov kom lawv noj cov probiotic, qhov zoo ntxiv ntawd yog tsawg kawg yog nyob ntawm no hauv UK, tej zaum hauv Tebchaws Europe thiab Tebchaws Meskas thiab, tias nws tsis yog ib qho tshuaj [00:18:00]. Yog li koj tuaj yeem muaj qhov no yam tsis tas yuav mus rau qhov kev nruj ntawm kev sau ntawv piv txwv li, ntau tus neeg mob noj cov tshuaj ntxiv, ntau tus neeg mob noj cov vitamins, thiab lwm yam, thiab lwm yam probiotics los ntawm cov khw muag khoom loj, cov khw muag khoom loj thiab lwm yam. Yog li cov neeg mob tuaj yeem siv cov probiotic tshwj xeeb no. Thiab muab cov ntaub ntawv, nws pab lub sijhawm kom ON uas yuav muaj qhov cuam tshuam meej meej ntawm lub cev muaj zog. Tab sis ntxiv rau qhov kev txhim kho hauv cov yam tsis yog lub cev muaj zog yog qhov txhawb siab heev.

Qhov mob raws plab, qhov qaug zog. Thiab qhov no rov qab mus rau tus neeg mob thawj qhov kev piav qhia. Ib qho tseem ceeb uas nws hais rau kuv ua ntej peb tham txog qhov kev sim no yog tias thaum nws noj tshuaj symprove, nws tau pab nws qaug zog, nws tau pab nws txoj kev noj qab haus huv, uas kuv xav tias tej zaum nws piav qhia txog qhov qaug zog.

Yog li nws zoo siab uas pom tias qhov ntawd tau cuam tshuam rau hauv cov ntaub ntawv uas tau tawm ntawm Valentina txoj kev tshawb fawb. [00:19:00] Tab sis kuj yog kev kho mob, kuv qhov kev xav txawm li cas los xij, tias nws yog cov khoom pom zoo thaum ntxov lossis txawm tias theem kawg ntawm Parkinson's, thaum twg muaj hnav OFF. Tsis muaj teeb meem hauv kev sim nws, tshwj xeeb, nws kuj tseem txhim kho kev noj qab haus huv ntawm txoj hnyuv.

Thiab raws li cov ntaub ntawv qhia tau tias muaj cov kev ua ntxiv tiv thaiv kev o, uas zoo li txhawb nqa heev nrog cov ntaub ntawv cytokine uas peb muaj.

Dr. Sara Schaefer: Txhua yam uas muaj cov ntaub ntawv los txhawb nws txoj kev siv rau kev qaug zog hauv Parkinson's yog qhov zoo siab ntxiv rau peb cov kev kho mob, puas yog? vim tias qhov ntawd tsuas yog ib yam nyuaj rau kho tshwj tsis yog tias muaj lwm yam tshwm sim, xws li pw tsaug zog apnea lossis ntshav siab qis. Thaum koj tshem tawm tag nrho cov khoom ntawd, tsis muaj ntau yam uas peb muaj hauv peb lub thawv cuab yeej.

Zoo kawg li uas qhov no yuav yog ib yam dab tsi uas yuav tsum xav txog. Tam sim no, Ray, koj pheej hais tias qhov no yog ib hom tshwj xeeb ntawm plaub hom probiotic, tab sis raws li peb txhua tus paub, muaj ntau lub hiav txwv ntawm probiotics nyob ntawd, ntau lub tuam txhab [00:20:00], ntau cov qauv, thiab lwm yam. Vim li cas cov probiotic tshwj xeeb no thiaj raug xaiv dua li qhov tseeb tias tus neeg mob no tau nthuav qhia rau koj tias qhov no yog qhov uas nws nyob ntawm?

Thiab koj yuav pom zoo li cas rau tus kws kho mob uas kho cov neeg mob Parkinson lossis tus neeg uas muaj tus kab mob Parkinson uas siv cov tshuaj probiotics uas lawv yuav tsum xaiv?

Dr. Kallol Ray Chaudhuri: Lo lus nug zoo heev, Sara. Kuv xav tias, qhov tseem ceeb uas yuav tsum paub ntawm no yog tias thaum cov ntaub ntawv tau nthuav tawm rau peb, ob leeg Valentina thiab kuv, peb tau pib ua raws li koj tau hais, saib cov pov thawj uas twb muaj lawm. Thiab peb pom tias plaub hom probiotic no twb tau siv rau lwm yam kab mob, tsis yog kab mob neurological, tab sis hauv cov kab mob plab. Thiab kuj muaj pov thawj zoo heev ntawm qhov no tau siv lawm hauv Clostridium difficile kab mob, qhov twg qhov sib txawv nrog qhov tshwj xeeb [00:21:00] probiotic no yog tias nws muaj kev nkag mus zoo heev rau hauv txoj hnyuv loj thiab mus rau hauv microbiota, uas koj zoo li tsis tau txais nrog ntau lwm yam probiotics uas muaj.

Tej zaum yuav muaj lwm cov probiotics uas ua tau li ntawd, tab sis peb tsis muaj pov thawj los txhawb nws. Yog li ntawd, qhov laj thawj uas peb tau xaiv los txhim kho rau cov probiotic tshwj xeeb no yog vim peb muaj pov thawj tias nws ua tau zoo hauv pawg Clostridium difficile, peb muaj nws cov ntaub ntawv ua tau zoo los ntawm kev tshawb fawb ua ntej hauv kev mob plab hnyuv thiab kuj muaj qee qhov kev paub ua ntej ntawm cov neeg mob Parkinson hais tias lawv xav tias zoo dua rau nws.

Yog li ntawd, qhov ntawd yog qhov sib sau ua ke, ib yam ntawm lub zog, yog tias koj xav li ntawd coj peb mus rau qhov no. Valentina, koj puas xav ntxiv rau qhov ntawd?

Dr. Valentina Leta: Tsuas yog hais tias ib qho ntawm cov teeb meem tseem ceeb tshaj plaws rau probiotic ua haujlwm yog tiag tiag kom muaj sia nyob hauv qhov chaw acidic ntawm lub plab. Thiab muaj kev tshawb fawb hauv vitro [00:22:00] qhov twg tus kws tshawb fawb, lawv simulate lub plab zom mov nrog lub acidity ntawm lub plab, thiab qhov no yog ib qho ntawm ob peb probiotics muaj peev xwm muaj sia nyob hauv qhov chaw acidic ntawm lub plab nrog cov kab mob ntawm kev muaj sia nyob. Yog li qhov no tseem ceeb heev. Thiab tseem, tsis txhob hnov ​​​​​​qab cov pov thawj preclinical ntawm kev siv cov probiotic tshwj xeeb no hauv cov qauv tsiaj ntawm Parkinson's. Qhov no yog qhov Ray tau hais ua ntej. Yog li muaj kev tshawb pom preclinical thiab kev kho mob, uas tau coj peb mus rau kev xaiv ntawm plaub hom probiotic tshwj xeeb no.

Dr. Sara Schaefer: Qhov ntawd pab tau heev. Valentina, koj tau hais tias, rau qhov kev tshawb fawb tshwj xeeb no koj tau xaiv cov neeg mob uas muaj cem quav thiab tus kab mob Parkinson. Yog li ntawd, kev koom tes ntawm GI meej meej. Kuv xav tsis thoob tias koj puas tuaj yeem qhia rau peb paub seb koj puas xav tias yuav muaj cov neeg mob [00:23:00] sab nraud ntawm pawg neeg nqaim ntawd uas yuav tau txais txiaj ntsig tsuas yog vim muaj cov khoom tiv thaiv kev o, lossis peb puas tuaj yeem xav tias tsuas yog cov neeg mob uas muaj cem quav muaj qhov tsis zoo ntawm txoj hnyuv hauv tus kab mob Parkinson?

Dr. Valentina Leta: Ua tsaug, Sara, rau qhov koj hais txog qhov tseem ceeb no. Muaj pov thawj qhia tias txawm tias tus neeg mob Parkinson uas tsis muaj cem quav los kuj muaj qee yam teeb meem ntawm txoj hnyuv. Lawv, lawv cov kab mob hauv plab kuj yuav hloov pauv thiab. Yog li ntawd, txawm tias tsis muaj cem quav los xij, tej zaum yuav muaj qee yam teeb meem ntawm txoj hnyuv.

Txawm li cas los xij, peb yuav tsum muaj pov thawj ntxiv los qhia txog kev cuam tshuam ntawm cov kab mob hauv plab hauv cov neeg mob no vim tias lub sijhawm no peb paub tias lawv yuav pab tau rau kev cem quav. Thiab muaj qee cov cim zoo uas peb tau hais.

Cov kauj ruam tom ntej yuav yog [00:24:00] qhov tseem ceeb yog teeb tsa cov kev sim tshuaj loj dua, saib cov yam ntxwv tshwj xeeb ntawm lub cev muaj zog thiab cov yam ntxwv tsis yog lub cev muaj zog kom paub meej cov kev tshawb pom no, thiab tej zaum yuav muaj peev xwm qhia cov probiotics rau cov neeg mob uas muaj kev hloov pauv nrog lub sijhawm qeeb mus rau ON lossis qaug zog.

Tam sim no peb yuav tsum ua kom paub tseeb tias cov kev tshawb pom no.

Dr. Kallol Ray Chaudhuri: Yog lawm. Qhov tseeb, peb tab tom ua li ntawd nrog Valentina thiab kuv, peb tab tom sim muab tso ua ke tam sim no kev tshawb fawb qhib, lub neej tiag tiag thoob plaws ntau lub chaw thoob plaws ntiaj teb vim peb xav saib ntau haiv neeg, ntau haiv neeg, kev noj zaub mov, ntau hom kev noj zaub mov. Cov ntaub ntawv no siv tau rau cov neeg mob Esxias, rau cov neeg mob dub African lossis lwm yam.

Yog li peb xav ua ib txoj kev tshawb fawb loj heev txog ntau haiv neeg tsuas yog ib txoj kev tshawb fawb txog kev kam rau siab, tab sis tej zaum kuj hais txog, raws li koj tau taw qhia, Sara, [00:25:00] qaug zog. Uas yog ib qho teeb meem rau peb. Cov neeg uas muaj Parkinson's, thiab rau peb cov neeg uas nyob hauv kev kho mob. Yog li peb xav ua ib yam dab tsi zoo li ntawd.

Dr. Sara Schaefer: Zoo, kuv yeej tos ntsoov cov kauj ruam tom ntej thiab cov ntaub ntawv tom ntej. Nej puas muaj lus xaus lus dab tsi?

Dr. Valentina Leta: Kuv ntseeg tias qhov no yog ib qho chaw uas yuav tsum tau tshawb nrhiav ntxiv. Muaj. Qee cov pov thawj muaj zog qhia tias cov kab mob hauv plab ua lub luag haujlwm hauv tib neeg kev noj qab haus huv thiab cov kab mob xws li cov kab mob Parkinson. Yog li nws yog ib qho tseem ceeb heev uas yuav tsum tshawb nrhiav ntxiv txog kev siv cov kab mob hauv plab kom pom tseeb txog qhov cuam tshuam ntawm cov kev cuam tshuam no rau cov tsos mob ntawm tus kab mob Parkinson thiab kom nkag siab tiag tiag yog dab tsi yog cov txheej txheem uas txhawb nqa cov txiaj ntsig zoo no.

Dr. Kallol Ray Chaudhuri: Kuv pom zoo tag nrho li ntawd. Tab sis kuv kuj xav ntxiv qhov ntawd [00:26:00] nthuav yog Lub Koom Haum Kev Mob Hlwb, zoo li muaj ib pawg kev tshawb fawb tshwj xeeb tam sim no txog kev noj qab haus huv hauv Parkinson, coj los ntawm Idu Subramanian thiab nws cov npoj yaig. Thiab kev noj qab haus huv ntawm cov neeg tseem ceeb ntawm kev noj qab haus huv yog kev noj qab haus huv ntawm txoj hnyuv hauv Parkinson.

Yog li ntawd, peb xav tias qhov no yog ib kauj ruam tseem ceeb heev rau pem hauv ntej los ntawm kev siv cov khoom uas yooj yim nrhiav tau uas tsis yog tshuaj, muaj kev nyab xeeb, uas peb siv thiab feem ntau ntawm peb yog cov probiotic heev, yog tias koj xav tau. Peb coob tus siv cov tshuaj noj qab haus huv txawm tias koj tsis muaj Parkinson's. Yog li kev muaj cov khoom zoo li no, uas zoo li no, raws li pov thawj tam sim no theem ib pov thawj los txhawb qhov ntawd tsuas yog ib kauj ruam mus rau tag nrho lub tswv yim ntawm kev noj qab haus huv hauv Parkinson's yav tom ntej.

Thiab peb vam tias peb txoj kev tshawb fawb thoob ntiaj teb ntxiv yuav ua rau cov ntaub ntawv no sib sau ua ke ntxiv.

Dr. Sara Schaefer: Zoo kawg nkaus li. Kuv tsis paub [00:27:00] txog pawg kawm ntawd, tab sis kuv xav tias kuv xav koom nrog nws. Qhov kev pom ntawm tus neeg mob thiab kev xav txog kev noj qab haus huv. Kuv nyiam qhov kev xav ntawd. Ua tsaug rau nej ob leeg heev rau kev koom nrog peb hnub no thiab qhia cov txiaj ntsig no rau peb.

Dr. Kallol Ray Chaudhuri: Ua tsaug ntau ntau thiab ua tsaug, Valentina rau tag nrho koj txoj haujlwm.

Dr. Valentina Leta: Ua tsaug, Ray, rau koj txoj kev qhia. [00:28:00]